Journal article
Compartmentalization of innate immune responses in the central nervous system during cryptococcal meningitis/HIV coinfection
V Naranbhai, CC Chang, R Durgiah, S Omarjee, A Lim, MYS Moosa, JH Elliot, T Ndung'u, SR Lewin, MA French, WH Carr
AIDS | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014
Abstract
Objective: The role of innate immunity in the pathogenesis of cryptococcal meningitis is unclear. We hypothesized that natural killer (NK) cell and monocyte responses show central nervous system (CNS) compartment-specific profiles, and are altered by antifungal therapy and combination antiretroviral therapy (cART) during cryptococcal meningitis/HIV coinfection. Design: Substudy of a prospective cohort study of adults with cryptococcal meningitis/HIV coinfection in Durban, South Africa. Methods: We used multiparametric flow cytometry to study compartmentalization of subsets, CD69 (a marker of activation), CXCR3 and CX3CR1 expression, and cytokine secretion of NK cells and monocytes in freshly..
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Awarded by National Institutes of Health
Funding Acknowledgements
This study was supported by the South African HIV/AIDS Research Platform (SHARP), the REACH initiative grant 2007, and US National Institutes for Health FIC K01-TW007793. V.N. was supported by LIFELab and the Columbia University-South Africa Fogarty AIDS International Training and Research Program (AITRP, grant #D43 TW000231). C. C. C. was supported by an Australian Postgraduate Award 2009, Australian National Health and Medical Research Council (NHMRC) Postgraduate Scholarship 2010-2012. S. R. L. is a NHMRC Practitioner Fellow. T.N. holds the South African Research Chair in Systems Biology of HIV/AIDS and is a Howard Hughes Medical Institute International Early Career Scientist. Additional training was supported by the South African National Research Foundation KISC Award.